Refine your search
Co-Authors
Journals
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Jadhav, S. D.
- Neuropharmacological Profile of Aqueous and Ethanolic Extract of Pithecellobium dulce Benth Leaves in Mice
Abstract Views :270 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmacology, Tatyasaheb Kore College of Pharmacy, A/P: Warananagar - 416113, Tal: Panhala, Dist: Kolhapur, Maharashtra, IN
2 Tatyasaheb Kore College of Pharmacy, Warananagar - 416113, Maharashtra, IN
1 Department of Pharmacology, Tatyasaheb Kore College of Pharmacy, A/P: Warananagar - 416113, Tal: Panhala, Dist: Kolhapur, Maharashtra, IN
2 Tatyasaheb Kore College of Pharmacy, Warananagar - 416113, Maharashtra, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 1 (2011), Pagination: 27-30Abstract
The present study was undertaken to evaluate several neuropharmacological activities of the aqueous and ethanolic extracts of Pithecellobium dulce Benth (Leguminosae) leaves in swiss albino mice. A crude extracts were given orally and its effects were tested on spontaneous motor activity, motor coordination, sodium pentobarbital-induced hypnosis and pentylenetetrazole (PTZ)-induced convulsions. The leaves of plant were extracted with water and ethanol by maceration and soxhelation respectively. Preliminary phytochemical screening of both extracts was carried out to determine the nature of phytoconstituents present in it. Acute toxicity studies of the both extracts were performed using mice and dose of 200 mg/kg was selected for further studies. Results from experimental models showed prominent decrease in locomotor activity and motor coordination for both extracts. In sodium pentobarbital-induced hypnosis both extracts exhibited significant hypnotic effect. Results of anticonvulsant activity testing by PTZ method revealed that aqueous and ethanolic extract of Pithecellobium dulce could not decreased the convulsions as well as mortality in mice. In conclusion, this study demonstrates that an acutely administered single dose of an aqueous and ethanolic extracts of Pithecellobium dulce leaves possess skeletal muscle relaxation activity and can exert depressant effects on the CNS but no anticonvulsant action.Keywords
Pithecellobium dulce, Neuropharmacology, Depressant, Hypnotic.
References
- Kirtikar KR and Basu BD. Indian medicinal plants Vol. II. International Book Distributors, Dehradun. 1975.
- Sugumaran M et al. Antidiabetic potential of aqueous and alcoholic leaf extracts of Pithecellobium dulce. Asian J of Research in Chem. 2009; 2(1): 83-85.
- Zapesochnaya GG et al. Flavonoids of the leaves of Pithecellobium dulce. Khim Prir Soedin. 1980; 2:252.
- Megala J and Geetha A. Free radical-scavenging and H+, K+- ATPase inhibition activities of Pithecellobium. Food Chemistry. 2010; 121:1120-1128.
- Khare CP. Indian medicinal plants, an illustrated dictionary. Springer (India) Private Limited, New Delhi. 2007.
- Murugesansugumaran. Pithecellobium Dulce Benth - A Review. Pharmainfo.net. 2008; 6(3). Available from: URL: http://www.pharmainfo.net/reviews/ pithecellobium-dulcebenth-review.
- Shanmugakumaran SD et al. Pharmacognostical, antibacterial and antifungal potentials of the leaf extracts of Pithecellobium dulce Benth. Phcog Mag. 2006; 7(2): 163-167.
- Sahu NP and Mahato SB. Anti-inflammatory triterpene saponins of Pithecellobium dulce: Characterization of an echinocystic acid bisdesmoside. The International J Plant Biochem. 1994; 37(5): 1425-1427.
- Ghosh MN. Fundamentals of experimental pharmacology. Scientific book agency, Calcutta.1984.
- Kulkarni SK. Hand book of experimental pharmacology. Vallabh Prakashan, New Delhi. 1999.
- Kasture SB. A handbook of experiments in pre-clinical pharmacology. Career publication, Nasik, 2006.
- Carlini EA et al. Pharmacology of lemongrass (Cymbopogon citratus Stapf) I. Effects of teas prepared from the leaves on laboratory animals. Journal of Ethnopharmacology. 1986; 17:37-64.
- Speroni E and Minghetti A. Neuropharmacology activity of extracts from Passiflora incarnata. Planta Medica. 1988; 54:488-491.
- Leewanich P et al. Behavioural studies on alkaloids extracted from leaves of Hunteria zeylanica. Biological and Pharmaceutical Bulletin. 1996; 19:394-399.
- Nagarjun NS et al. CNS depressant activity of Dalbergia malaberica. Indian Drugs. 2003; 40:716-717.
- Carpendo R et al. Inhibitors of kynurenrie hydroxylase and kynureniase increase cerebral formation of kynurenate and have sedative and anti-convulsant activities. Neuroscience. 1994; 61:237-243.
- Gouemo PN et al. Some neuropharmacological effects of an ethanolic extract of Maprounea africana in rodents. Journal of Ethnopharmacology. 1994; 62:57-263.
- Kaul PN and Kulkarni SK. New drug metabolism inhibitor of marine origin. Journal Pharmaceutical Sciences. 1978; 67:1293-1296.
- Fujimori H. Potentiation of barbital hypnosis as an evaluation method for central nervous system depressant. Psychopharmacology. 1965; 7:374-377.
- Petty F. GABA and mood disorders: a brief review and hypothesis. Journal of Affective Disorders 1995; 34:275-281.
- Swinyard EA et al. Experimental selection, quantification and evaluation of anticonvulsants. In: Levy, R., Mattson, R., Meldrum, B.S., Penry, J.K., Dreifuss, F.E. (Eds.), Antiepileptic Drugs. Raven Press, New York. 1989; 3rd ed: pp. 85-102.
- Ramanjaneyulu R and Ticku MK. Interactions of pentamethylenetetrazole and tetrazole analogues with the picrotoxinin site of the benzodiazepine-GABA receptor ionophore complex. Eur Journal of Pharmacol. 1984; 98:337-345.
- Groundwater Quality of Gadhinglaj Tahsil of Maharashtra
Abstract Views :140 |
PDF Views:0
Authors
Affiliations
1 Department of Botany, Dr. Ghali College, Gadhinglaj-416 502, District Kolhapur, Maharashtra, IN
1 Department of Botany, Dr. Ghali College, Gadhinglaj-416 502, District Kolhapur, Maharashtra, IN
Source
Nature Environment and Pollution Technology, Vol 10, No 4 (2011), Pagination: 613-616Abstract
The study deals with the groundwater quality of Gadhinglaj tehsil in Maharashtra. The groundwater quality was assessed by examining various physico-chemical parameters. The borewell water samples were collected from 40 villages from Gadhinglaj tehsil during winter season. The physico-chemical parameters like temperature, pH, EC, free CO2, total alkalinity, total hardness, Ca and Mg hardness, chlorides and dissolved oxygen were analysed. The result were compared with WHO and BIS standards. Except for a few parameters at some places, most of the water samples were found to be suitable for drinking.Keywords
Groundwater Quality, Borewells, Gadhinglaj Tehsil, Drinking Water Standards.Full Text
- Development and Validation of Method for Simultaneous Estimation of Lamivudine, Zidovudine and Nevirapine
Abstract Views :173 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Tatyasaheb Kore College of Pharmacy, Warananagar-416113 (M.S.), IN
2 Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Morewadi, Kolhapur-416013 (M.S.), IN
1 Department of Pharmaceutical Chemistry, Tatyasaheb Kore College of Pharmacy, Warananagar-416113 (M.S.), IN
2 Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Morewadi, Kolhapur-416013 (M.S.), IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 4 (2010), Pagination: 995-997Abstract
Lamivudine (LMV), Zidovudine (ZDV) and Nevirapine (NVR) are used in combination for treatment of HIV I. The present work deals with method development for simultaneous estimation of these drugs in tablet dosage form by UV spectrophotometry. A new simple, accurate and sensitive method for simultaneous estimation of lamivudine, zidovudine and nevirapine from tablet formulation has been developed. The method employs combination of zero order and first order derivative spectroscopy. Estimation of nevirapine was done in zero order derivative mode at 310 nm where zidovudine and lamivudine do not show any interference. Estimation of zidovudine was done in first order derivative mode at 270 nm where lamivudine and nevirapine shows zero crossing points. Estimation of lamivudine is done in zero order derivative mode at 271 nm by correcting the absorbance interferences due to zidovudine and nevirapine. Absorbance interferences of zidovudine and nevirapine calculated from their absorptivities. The results of analysis validated statistically and recovery studies showed satisfactory results. Thus the method is accurate and reproducible and can be employed for routine analysis of these drugs from tablet dosage forms.Keywords
Lamivudine, Zidovudine, Nevirapine, Absorbance Interferences.- Development and Validation of Method for Simultaneous Estimation of Atorvastatin Calcium and Ramipril from Capsule Dosage Form by First Order Derivative Spectroscopy
Abstract Views :178 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur-416013, IN
1 Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur-416013, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 1 (2009), Pagination: 52-53Abstract
Atorvastatin Calcium and Ramipril are used in combination for treatment of hypertension. The present work deals with simple spectrophotometric method development for simultaneous estimation of Atorvastatin Calcium (ATR) and Ramipril (RAM) in two component capsule formulation. The method employed first order derivative spectroscopy. For determination of sampling wavelength 10 μg/ml of each of ATR and RAM were scanned in 200-350 nm range and sampling wavelengths were 294 nm for ATR were RAM showed zero crossing point and 229 nm for RAM were ATR showed zero crossing point in first order derivative spectroscopy. For this method linearity observed in 5-40 μg/ml for ATR and 2-20 μg/ml for RAM. The recovery studies confirmed accuracy of proposed method and low values of standard deviation confirmed precision of method. The method is validated as per ICH guidelines.Keywords
Atorvastatin Calcium, Ramipril, Derivative Spectroscopy.- Development and Quality Evaluation of Unriped Mango and Aloe-Vera RTS (Ready to Serve) Beverage
Abstract Views :320 |
PDF Views:0
Authors
Affiliations
1 Department of Agricultural Process Engineering, K.K. Wagh College of Agriculture Engineering and Technology, Nashik (M.S.), IN
2 Department of Agricultural Engineering, K.K. Wagh College of Agriculture Engineering and Technology, Nashik (M.S.), IN
1 Department of Agricultural Process Engineering, K.K. Wagh College of Agriculture Engineering and Technology, Nashik (M.S.), IN
2 Department of Agricultural Engineering, K.K. Wagh College of Agriculture Engineering and Technology, Nashik (M.S.), IN
Source
International Journal of Processing and Post harvest Technology, Vol 9, No 1 (2018), Pagination: 34-38Abstract
The present research work was undertaken to develop the technology for development and quality evaluation of unriped mango and Aloe vera RTS beverage prepared from unriped mango juice and Aloe vera juice and to study the changes in chemical composition and sensory qualities of the RTS with different proportions of juice of unriped mango and Aloe vera held at the department of Agricultural Process Engineering, K.K Wagh College of Agriculture Engineering and Technology. Different treatments were used for the study using different proportion of juice of unriped mango and Aloe vera namely T1, T2 and T3. On the basis of sensory score and physio-chemical composition we found that treatment T3 (60:40) was found best.Keywords
RTS, Chemical Analysis, Sensory Evalution.References
- Ara, R., Motalab, M.,Uddin, M. N., Fakhruddin, A. N. M. and Saha, B. K. (2014). Nutritional evaluation of different mango varieties available in Bangladesh. Internat. Food Res. J., 21 (6) : 2169-2174.
- Boghani, A.H., Raheem, A. and Hashmi, S.I. (2012). Development and storage studies of blended papaya-Aloe vera ready to serve (RTS) beverage; Food Process & Technol., 3 (10): 1-5.
- Chauhan, D.K., Puranik, V. and Rai, G. K. (2012). Development of functional herbal RTS beverage; Open Access Scientif. Reports, 1(12): 1-5.
- Gopakumar, A.S. and Kavita, M.S. (2014). Processing and preservation qualities of value added products based on Garciniacambogia (Malabar tamarind). IOSR J. Environ. Sci. Toxicol. & Food Technol., 8 (1) : 01-09.
- Kausar, H., Parveen, S., Saeed, S., Ishfaq, B. and Ali, M.A. (2016). Development and standardization of ready to serve Aloe vera lemon functional drink, J. Environ. Sci. Toxicol. & Food Technol., 10 (4): 47-52.
- Sasikumar, R. (2015). Preparation of therapeutic RTS beverage from Aloe vera gel and aonla fruit juice and evaluation of storage stability; Asian J. Dairy & Food Res., 3 (2): 151-155.
- Sasikumar, R. and Vivek, K. (2015). Process development of therapeutic RTS beverage from blend of Aloe vera and pine apple, J. Agric. Technol., 2 (1&2): 7-12.
- Sharma, R., Tandon, D., Joshi, V.K. and Attri, S. (2015). Development and evaluation of different beverages from Aloe-vera (L.) Burm.f. for their nutritional, functional and sensory qualities; Indian J. Nat. Prod. & Resour., 6 (4): 278-282.
- Shobana, V. and Rajalakshmi, K. (2010). Quantitative analysis of primary metabolites in Mangifera indica (Unripem mango). Rasayan J. Chem., 3 (3): 597-599.